Digital Revolution

We are going to discuss here about a true breakthrough that has deep and far reaching ramifications for health and healing...the frontier of digitized information in homeopathic remedies.

It is now possible that the specific activity of biologically-active molecules (e.g., histamine, caffeine, adrenalin), not to mention the immunological electromagnetic signature of a virus or bacterium, can be recorded and digitized using a computer sound card, just like an ordinary sound. As we will see life depends on signals exchanged among molecules.

In biology, the phrase "molecular signal" is used often. Yet, biologists are not aware of what the physical nature of this signal is.

We have known for decades that molecules vibrate. Every atom of every molecule and every intermolecular bond-the bridge that links the atoms-emits a group of specific frequencies. Specific frequencies of simple or complex molecules are being detected at distances of billions of light-years, thanks to radio-telescopes. Biophysicists describe these frequencies as an essential physical characteristic of matter, but biologists and biochemists do not consider that electromagnetic waves can play a role in molecular functions themselves.

Now we are going to review some of the work of various renowned researchers who are responsible for opening up this new frontier we call "digital healing".

Benveniste

Experiments by Benveniste have shown that we can capture specific molecular signals by using an amplifier and electromagnetic coils. In July, 1995, he recorded and replayed these signals using a multimedia computer. A computer sound card only records frequencies up to about 20,000 Hz. In the course of many experiments, he had led receptors (specific to simple or complex molecules) to "believe" that they are in the presence of their favorite molecules by playing the recorded frequencies of those molecules. In order to arrive at this result, two operations are necessary: 1) record the activity of the substance on a computer, 2) "replay" it to a biological system, sensitive to the same substance. Therefore, there is every reason to think that when a molecule itself is in the presence of its receptor, it does the same thing: it emits frequencies which the receptor is capable of recognizing.

This means that a molecular signal can be efficiently represented by a spectrum of frequencies between 20Hz and 20,000 Hz, the same range as the human hearing or music. For several hundred thousand years, human beings have been relating sound frequencies to a biological mechanism: the emotions. Composers of background music for supermarkets or elevators are practicing neuron-psychology. High-pitched rapid sounds stimulate lightness of spirit, high-pitched slow sounds produce sweetness, and sounds both deep and rapid rouse the fighting spirit, while deep, slow sounds raise serious emotions, sadness and mourning. These are fundamentally cerebral physico-chemical phenomena, triggered by distinct frequencies. This is what we accomplish when we transmit recorded electromagnetic signatures to biological systems. Biological systems function like radio sets, operating by co-resonance. If you tune a receiver to 108 MHz, you tune in the radio transmitting frequency of 108 MHz because the receiver and the transmitter vibrate at the same frequency.

The electromagnetic nature of the molecular signal sheds light on many shadowy areas of biology. We can now understand how millions of biological molecules can communicate (at the speed of light), each with its own corresponding molecule, and it alone. Water is the vehicle for information. This cannot be avoided, since there are 10,000 water molecules in the human body for every molecule of protein. A submarine communicates with its base via low-frequency electromagnetic waves, not with megahertz frequencies, which do not penetrate water.

Experiments show that a molecule at a normally active concentration does not work in a medium devoid of water. Adding water is not enough to restore activity; it must be "informational." In other words, when molecules trigger a biological effect, they are not directly transmitting the signal. The final job is done by perimolecular water which relays and possibly amplifies the signal. Sound is not directly created by a compact disc. The latter carries data which is audible only after being amplified by an electronic system.

What interests us is not the nature of the magnetic medium and how it functions, but the message recorded in it, which can be copied and transmitted.

The Current Theory: "structural matching"	The Proposed Theory: "electromagnetic signals"

The Current Theory (structural matching)
vs. the Proposed Theory (electromagnetic signals)

The presently dominant QSAR (quantitative structure-activity relationship) theory of molecular signaling claims that two structurally matching molecular objects exchange specific information by mere contact (sometimes also referred to as the Key/Keyhole interaction model). Specific molecular interactions happen after random collisions between partners on a trial-and-error basis, using electrostatic, short range (two to three times the molecule size) forces. But this kind of random encounter, among many molecules which are foreign to a given biochemical reaction, would give to these meetings statistically little chance of occurring. Thus, the simplest biological event might require a very long time to happen.

Using various experimental protocols we are able to activate specific cell functions with the corresponding low frequency (<20 kHz) electromagnetic waves. This prompted us to hypothesize that the molecular signal is composed of such low frequency waves and that the ligand co-resonates with the receptor pretty much as the tuning of a radio device.

It is well-documented that:
1) Molecules emit specific frequencies.
2) A complex set of high frequency waves can produce low frequencies according to the "beat frequency" phenomenon.
3) All biological interactions occur in water, since, on the average, there are ten thousand molecules of water per molecule of protein.

In 1998, Endler et al did a study on tadpoles that provides clear evidence of the effect of electromagnetic signals on biological systems. His research has been duplicated by ten other researchers at eight different universities.

Tadpoles from tree frogs were studied in their development. It is well known that thyroxine up to a dilution of 10(-8th) induces and accelerates metamorphosis from larvae to tadpoles. Homeopathic dilutions of thyroxine in the 10(-11th) to 10(-30th) actually inhibit morphogenesis. Control water without thyroxine or with no succession had no effect (see below).

Also, larvae which had been exposed to excitatory material doses of thyroxine were later exposed to a succussed 10(-8th) preparation, which was able to inhibit the previously stimulatory effect. This experiment provides proof of the homeopathic principle of Isopathy.

Finally, an experiment was conducted where electrical frequencies were acquired from a vile of potentized water with thyroxine and amplified. These signals were digitized and transmitted into pure water (without thyroxine). The result was that metamorphosis was again inhibited in comparison with controls (see below).

Water with its interactions with enzymes, cells, and tissues can be seen as more than just a lock and key mechanism. Electromagnetic field interaction in the experiment with tree frogs proved that homeopathic potencies are not just molecules in water, but electromagnetic field vehicles with specific frequency complexes.

This type of research goes beyond the molecular biology discipline and is more closely related to the bio-physical field of study.

Fritz Albert Popp

The phenomenon of how information is transmitted within living systems was and is being extensively studied by a bio-physicist named Fritz Albert Popp. He discovered that photons provided the vehicle for which information was transmitted. Photons are light particles without mass. They transmit information within a cell and between cells. He showed that DNA of living cells stores and releases photons. He called this “biophotonic emission”. The intensity is about 10 (18th) times lower than regular daylight. To study this phenomenon he developed an instrument called a photon multiplier which could detect the glow of a firefly 10 miles away. DNA uses a variety of frequencies as an information tool suggesting a feedback system of perfect communication through waves which encode and transfer information.

Another fascinating characteristic of photons is their coherence. In a healthy state the emission is more coherent than anything that man has ever developed. Quantum coherence means that subatomic particles are able to co-operate. These waves know about each other and are highly interlinked by bands of electromagnetic fields. They can communicate with each other. It is analogous to an orchestra where all photons are playing together but as individual instruments that are able to carry on playing individual parts. Therefore, biophotonic emission is a perfect communication system that transfers information to many cells across the body and to other bodies.

Another important characteristic of biophotons is that they follow biological rhythms (i.e., daily, weekly, monthly and annually). In healthy individuals the biophotons are extremely coherent and in rhythm with the world. In seriously ill people (i.e., cancer) they have lost their natural rhythm and coherence. The lines of communication were scrambled and they lost their connection with the world. In effect their light was going out.

Interestingly, Popp found in people with multiple sclerosis, that the opposite was true. They were in a state of too much order. They were taking in too much light, inhibiting the ability of the cells to do their job. Too much cooperative harmony prevented flexibility and individuality. In reality, they were drowning in their light.

In a stressed state, the rate of biophotonic emissions went up. This is a defense mechanism to try and return to homeostasis. Therefore biophotonic emission is a sort of correction mechanism in living systems.
 
Studying food, Popp found that the healthiest food has the lowest and most coherent intensity of light.

William Ross Adey

The final important principle looks at the actual intensity of the emission. William Ross Adey, while experimenting with cerebral cells in chicks, found they only responded to a certain frequency (10 Hz). Also, he found that the amplitude must lie within a specific (very low) range. This is called Adey’s window, and it is a limited range in which a biological system is able to respond to electromagnetic signals carrying information. Interestingly, this range falls within the same range in which Homeopathic signals are measured.

Popp found while studying Homeopathic remedies that they are an example of photon sucking. Homeopathic remedies are resonance absorbers. If a non-physiological frequency produces certain symptoms, a high dilution of a substance which could produce the same symptoms would still carry these oscillations. Like a tuning fork in resonance, a suitable homeopathic solution might attract and then absorb the non-physiological oscillations, allowing the body to return to normal.

Biophysical Controls Biochemistry

ALL BIOCHEMICAL REACTIONS IN LIVING ORGANISMS ARE OPERATED AND REGULATED BY LOW ELECTROMAGNETIC FREQUENCIES.

The implications of this statement are numerous and extremely important, not the least of which is that the biophysical level of an organism controls its biochemistry. For example, changing and adjusting the biochemistry of the human body can easily be accomplished with medications, supplements, diet, and even exercise, but this is only dealing with a disease state at a symptomatic level. However, affecting change at the biophysical level where cellular communication can be normalized will result in a balance of both the biophysical and biochemical levels. And how does one affect this type of change? Based on what we’ve learned from the research of Benveniste, Popp, and Adey, the answer is digital homeopathy.

 

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Abstract FASEB Journal, 1999, vol. 13, p. A852
SPECIFIC REMOTE DETECTION OF BACTERIA USING AN ELECTROMAGNETIC / DIGITAL PROCEDURE
J. Benveniste, L. Kahhak, and D. Guillonnet. Digital Biology Laboratory, F-92140 Clamart.
Previous studies suggest that the electromagnetic molecular signal (EMS) can be digitally recorded and replayed [1-4]. We electronically captured, digitized, and transmitted the specific EMS of bacteria to a biological system sensitive to this EMS. First we digitally recorded EMS from E.coli K1, staphylococcus (3.5 million/ml) or saline. Latex particles, sensitized by a K1 antibody (ab), aggregate to E.coli K1 (kit, Pasteur Diagnostics). We then set up the ab-latex and E.coli antigen (ag) concentrations so as to obtain minimal aggregation. Next, we applied the E.coli or control recorded EMS for 2 min to ab-latex and ag which we subsequently mixed. After allowing the mixture to migrate for 13 min at 37°C in a capillary, we examined it under a microscope. A CCD camera generated 3 pictures that were analyzed using a dedicated software. E.coli K1 EMS induced the formation of larger aggregates than that of Staphylococcus or saline. The magnitude of aggregation varied from day to day. Yet, by comparing E.coli data from controls of the same day, we seldom failed to detect E.coli in hundreds of experiments (mean of differences: 150 %). Thus, we are clearly able to identify a bacteria by playing its EMS signal. The latter is specific, since the effect of staphylococcus EMS on E.coli ag/ab reaction was close to that of saline. Since EMS travel a long distance in the form of a ".wav" file, it should become possible to detect any immunogenic substance from a remote location.
[1] Davenas et al., Eur. J. Pharmacol., 1987, 135:313; [2] Davenas et al., Nature, 1988, 333:816; [3] Aïssa et al., J. Immunol., 1993, 150:A146; [4] Benveniste et al., J. Allergy Clin. Immunol., 1997, 99:S175. Supported by DigiBio S.A.

Abstract
MODULATION OF HUMAN NEUTROPHIL ACTIVATION BY "ELECTRONIC" PHORBOL MYRISTATE ACETATE (PMA).
Yolène Thomas, Hedi Litime and ,Jacques Benveniste. CNRS URA 1442, 60206 Compiègne and Digital Biology, laboratory, 32 rue des Carnets, 92140 Clamart, France.
The molecular signal of PMA can be electronically transmitted and modulate neutrophil reactive oxygen metabolite (ROM) production as if PMA itself was added to the cells [1]. Experiments reported here were done blind or open at INSERM U 332, ICGM, Paris. Transmission was performed via an especially designed amplifier connected to two coils [2]. The source tube containing PMA (1 µM) or vehicle was placed on the input coil at RT, and target cells (1 million per ml) on the output coil ait 37° C in a humidified incubator. The amplifier was then turned on for 15 min transmission time and cells were then incubated for up to 45 min before measurement of cytochrome c reduction. Three or four amplifiers were used simultaneously for each experiment. An increase in ROM production was observed immediately after PMA transmission: (over vehicle transmission), 56.6 +- 15.5 %, mean +- SEM, and up to 60 min: 38.7 +- 14.8, n = 9. Peak PMA transmission effect varied among individuals. Transmission of 4alpha-phorbol 12,13-dibutyrate, an inactive PMA analogue, did not stimulate neutrophil ROM production. The effect of PMA transmission was inhibited when 1) the amplifier was switched off: 42 ± 8 % vs -1.8 ±1.4 %, n = 6, and 2) the selective protein kinase C inhibitor GF109203X was added to the cells (8 µM) before PMA transmission.
These results, together with those previously reported, suggest that molecules emit signals than can be transferred to cells by artificial physical means in a manner that seems specific to the source molecules.
[1] Thomas et al., FASEB J. 1995, 9:A227; [2] Benveniste et al., FASEB J. 1994, 8: A398. Supported in part by Ministère de l'Environnement, Bouygues SA, SAUR, and Association Science Innovante.

Abstract
DIGITAL RECORDING/TRANSMISSION OF THE CHOLINERGIC SIGNAL.
J. Benveniste, P. Jurgens and J. Aissa. INSERM U 200 and Digital Biology 'Laboratory, 32 rue des Carnets, 92140 Clamart, France.
Previous studies suggest that the biological activity of agonists can be transferred to water by electromagnetic means [1-7]. Since July 1995, in keeping with these results, we have digitized, recorded, and 'replayed' to water the activity of acetylcholine (ACh) or water (W) as control. ACh and W were recorded (16 bits, 22 KHz), for 1-5 sec, via an especially designed transducer, on the hard disk of a computer equipped with a Sound Blaster 16 card. Files were digitally amplified and the signal of digitally recorded ACh or W was replayed for 15 min, via the transducer, to 15 ml, W-containing plastic tubes. W thus exposed (dACh, dW), was then perfused to isolated guinea-pig hearts. In 13 open experiments, coronary flow variations were (%, mean +- SEM, nb of samples): W+dW(not stat. diff.), 3.3 +- 0.2, 20; dACh, 16.2 +- 1.0, 33, p = 4.1 e- 10 vs W+dW; ACh (0.1 µM), 23.4 +- 2.8, 12, P = 5 e-3 vs dACh. In 25 blind experiments: W+dW, 3.6 +- 0.3, 61; dACh, 20.4 +- 1.3, 58, p = 1 e- 16 vs W+dW; ACh (0.1 pM), 28.1 +- 2.3, 24, p = 3 e-3 vs dACh. Atropine inhibited the effects of both ACh and dACh. Moreover, we have recently transferred specific digital signals via telephone lines.
These results indicate that the molecular signal is composed of waveforms in the 0-22 Khz range. They open the way to purely digital procedures for the analysis, modification and transmission of molecular activity.
[1] Aissa et al., FASEB J. 1993, 7:A602; [2] Benveniste et al., FASEB J. 1994, 8: A398; [3] Aissa et al., J. Immunol. 1993, 150:Al46; [4] Aissa et al., FASEB J. 1995, 9:A425; [5] Citro et al., FASEB J. 1995, 9:A392; [6] Senekowitsch et al., FASEB J. 1995, 9:A392; [7] Thomas et al., FASEB J. 1995, 9:A227. Supported in part by Bouygues SA, SAUR, Dolisos, LSH and Association Science Innovante.

Abstract
J. Allergy Clin. Immunol. 99:S175, 1997
TRANSATLANTIC TRANSFER OF DIGITIZED ANTIGEN SIGNAL BY TELEPHONE LINK.
J. Aïssa, P. Jurgens, W. Hsueh and J. Benveniste. Digital Biology Laboratory (DBL), 32 rue des Carnets, 92140 Clamart, France and NorthWestern University Medical School, Chicago, IL 60614, USA.
Ligands so dilute that no original molecule remained still retained biological activity which could be abolished by magnetic fields [1-3], suggesting the electromagnetic (EM) nature of the molecular signal. This was later confirmed by the electronic transfer to water (W) of molecular activity, either directly or after computer storage [4-7]. Here, we report its transfer via the telephone network. Ovalbumin (Ova) or W as control, was recorded (1 sec, 16 bits, 22 kHz) into a diskette in Chicago using a transducer and computer equipped with sound-card. Coded files were transferred to diskettes in DBL's computer as "attached documents" via Internet e-mail. After digital amplification they were replayed for 20 min via a transducer to 15 ml W-containing plastic tubes. Exposed W (dOva, dW), was then perfused to isolated hearts from Ova-immunized guinea-pigs. The heart operator was always blind while technical incidents revealed the identity of 4/19 files to the computer operator. Coronary flow variations were (%, mean+SEM, nb of measures): naive W (negative control), 4.9+0.3, 41; dW, 4.4+0.3, 58; dOva, 24.0+1.4, 30, p= 4.5 e -17 vs dW; Ova (0.1 µM, positive control), 28.9+3.7,19, ns vs dOva. The hitherto neglected physical nature of the molecular signal emerges: EM radiation under 22 kHz that can be digitized, transferred long distances and replayed to W, which then mimicks the activity of the source-molecule. This implies novel strategies in chemistry, biology and medicine. [1] Davenas et al., Nature. 1988, 333:816; [2] Benveniste et al., CR Acad Sci Paris. 1991, 312:461; [3] Benveniste et al., FASEB J. 1992, 6:A1610; [4,5] Aissa et al., FASEB J. 1993, 150:A146 & 1995, 9:A425; [6] Thomas et al., FASEB J. 1996, [7] Benveniste et al., FASEB J. 1996, 10:A1479. Supported by Association Science Innovante.

SPECIFICITY OF THE DIGITIZED MOLECULAR SIGNAL
J. Benveniste, J. Aïssa, P. Jurgens and W. Hsueh*
presented at Experimental Biology '98 (FASEB). San Francisco, April 20, 1998

Introduction
For several years, we have activated various biological systems using the electromagnetic (EM) signal of the agonist molecule instead of the molecule itself. Signals are applied electronically, in real time, to target cells or organs. Alternatively, they are digitally recorded on a computer, either directly, using a purpose-designed transducer, or via the public switched network, and then replayed [1-9]. One of the main questions in this complex process of detection, recording, transfer and replay, is the integrity of the applied signal, which is a prerequisite for the specific expression of the molecular signal. We therefore investigated the specificity of digitized EM signals of acetylcholine (d-ACh) and histamine (d-H).

Materials and Methods
Heart preparation.
Isolated hearts from male Hartley guinea-pigs, ~= 300 g, were perfused according to the Langendorff method using Krebs-Henseleit buffer (pH 7.4) gassed with O2/CO2, 95/5 %, at a pressure of 40 cm H2O at 37°C.
Recording.

ACh, or sodium acetate + choline chloride (AC) or H at 1µM, or water (W), were recorded (6 sec, 16 bits, 44 kHz) using a purpose- designed transducer and a computer equipped with a sound card.
Assays.

d-ACh and d-H were applied to isolated guinea-pig hearts, perfused or not with the ACh inhibitor atropine or the H1 receptor blocker, mepyramine, both at 1 µM. d-W or d-AC, and ACh or H (1 µM), were also applied as negative and positive controls respectively. Coronary flow was then measured every min for 30 min and changes were calculated as % maximal coronary flow variation compared to three "time 0" values. Student's t-test for unpaired variates (Plot 40, Sigma Plot) was used to assess statistical significance.
Mechanical parameters (min. and max. tension, heart rate) were observed and recorded using dedicated software.

RESULTS
The effects on the maximal variation in coronary flow are shown in Table 1. ACh, H (1 µM), d-ACh, d-H induced highly significant changes, whereas d-W or d-AC were indistinguishable from spontaneous flow variations.
Atropine inhibited both the effects of ACh and d-ACh, but not those of H and d-H. Mepyramine inhibited the effect of both H and d-H but not those of d-ACh.

Variations in coronary flow following application of d-ACh and d-H were highly significant compared with controls, d-W and d-AC.
A typical effect of d-ACh on heart frequency and its inhibition by atropine are shown (figure 1).
[Vasodilation was induced in guinea-pig skin by d-ACh, whereas d-AC was ineffective (figure 2).]

Table 1
Effect of the anticholinergic atropine or the anti-H1mepyramine on the coronary flow variation, in % ± 1 SD (nb of experiments), induced by d-ACh or d-H in isolated guinea-pig hearts

d-W: 4.6 ± 2.1 (28).
(a) : p < 0.05 (Student's t test for unpaired variates) vs d-AC
     ns vs ACh 1 µM
(b) : ns vs d-AC
(c) : ns vs d-ACh (no inhibition)
(d) : p < 0.05 vs ACh (no inhibitor)
(e) : ns vs ACh (no inhibitor)
(f) : p < 0.05 vs mepyramine, ns vs atropine.

Figure 1
Effect of ACh signal on hearth rate (bpm)
Inhibition by atropine
Parameter : Frequency    Channel # : 1

Figure 2
Skin reactions in a non-immunized guinea-pig,
scanned live, following intra-dermic injection of digital
acetylcholine ('computer-informed' water)
January 26, 1998

DISCUSSION
We have used a purpose-designed transducer and a sound card-equipped computer, to digitize, record and replay the signals of ACh and H to isolated perfused guinea-pig hearts.

EM signals of ACh and H influenced cardiac function in the same way as the original molecules did

The specificity of the digitized activity is evident in the fact that atropine inhibited both ACh and d-ACh, while mepyramine inhibited both H and d-H, indicating that the recorded signal interacts with the same receptor as the original molecule. These results demonstrate that at least some biologically active molecules are capable of transmitting their activity to target cells or organs in the form of electromagnetic radiation of less than 44 kHz that can be recorded, digitized and replayed.
We therefore suggest that:
1. The molecular signal consists of low frequency waveforms.
2. One of the biological roles of molecule-associated water may be to mediate this signal, a hypothesis supported by contemporary physical research [10, 11].
3. The digitized signal is specific to the originally recorded molecule. When applied to target cells or organs, it exerts the same effects as the agonist in molecular form and its effects are inhibited by the same antagonist.

CONCLUSION
These results indicate that the molecular signal is composed of waveforms in the 0-44 Khz range which are specific to each molecular entity. They open the way to purely digital procedures for the analysis, modification and transmission of molecular activity, with medical and possibly industrial applications.

REFERENCES
1. J. Aïssa, M.H. Litime, E. Attias, J. Benveniste (1993) Molecular signaling at high dilution or by means of electronic circuitry. J. Immunol. 150:146A (abs).
2. J. Aïssa, M.H. Litime, E. Attias, A. Allal, J. Benveniste (1993) Transfer of molecular signals via electronic circuitry. FASEB J. 7:A602 (abs).
3. J. Benveniste, J. Aïssa, M.H. Litime, G.Th. Tsangaris, Y. Thomas (1994) Transfer of the molecular signal by electronic amplification. FASEB J. 8:A398 (abs).
4. P.C. Endler, W. Pongratz, R. van Wijk, K. Waltl, H. Hilgers, R. Brandmaier (1994) Transmission of hormone information by non-molecular means. FASEB J. 8:A400 (abs).
5. Y. Thomas, M. Schiff, M.H. Litime, L. Belkadi, J. Benveniste (1995) Direct transmission to cells of a molecular signal (phorbol myristate acetate, PMA) via an electronic device. FASEB J. 9:A227 (abs).
6. F. Senekowitsch, P.C. Endler, W. Pontratz, C.W. Smith (1995) Hormone effects by CD record/replay. FASEB J. 9:A392 (abs).
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8. J.Benveniste, P.Jurgens, J.Aïssa (1996) Digital recording/transmission of the cholinergic signal. FASEB J.10:A1479 (abs).
9. J. Benveniste, J. Aïssa, P. Jurgens, W. Hsueh (1997) Transatlantic transfer of digitized antigen signal by telephone link. J Allergy Clin Immunol., 99: S175.
10. E. del Giudice, G. Preparata, G. Vitiello (1988) Water as a free electric dipole laser. Phys. Rev. Lett. 61:1085-1088.
11. Shui-Yin Lo, Angela Lo, Li Wen Chong, et al., "Physical Properties of Water with IE Structures," Modern Physics Letters B, 10,19 (1996):921-930.